Process for preparing intermediates for a combinatorial dihydrobenzopyran library

US5688997A · kind A · utility

Assignee

• PHARMACOPEIA, LLC · US

Inventors

• John J. Baldwin · Gwynedd Valley, US
• John Charles Reader · Princeton, US
• Lawrence W. Dillard · Hopewell, US
• Ge Li · Shanghai, CN
• Jonathan J. Burbaum · Cranbury, US
• Wenguang Zeng · Lawrenceville, US

Key dates

• Filing date: Jun 7, 1995
• Grant date: Nov 18, 1997
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B40/00
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Combinatorial libraries are disclosed which are represented by Formula I: EQU (T'-L).sub.q -S-C(O)-L'-II' I wherein: PA1 S is a solid support; T'-L- is an identifier residue; and -L'-II' is a ligand/linker residue. These libraries contain dihydrobenzopyrans of the formula: ##STR1## which interact (i.e., as agonists or antagonists) with .alpha. adrenergic receptors, dopamine receptors, .sigma.-opiate receptors, and K.sup.+ channels and are inhibitors of carbonic anhydrase isozymes. They are useful in the treatment of ocular diseases such as glaucoma.