Genetic markers to detect high bone mass
US5691153A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 6, 1996 |
| Grant date | Nov 25, 1997 |
| Priority date | — |
| Expiry date | Sep 6, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/172
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides the chromosome location of an autosomal dominant gene associated with high bone mass. As a result of this localization, the presence of a polymorphism linked to the autosomal dominant gene in a subject can be detected by analyzing human chromosome 11 of the subject for the presence of the polymorphism located about 30 cM around D11S987 and linked to the autosomal dominant gene. The analysis of chromosome 11 can be accomplished by amplifying the polymorphism, separating the amplified polymorphism to generate a polymorphism pattern, and correlating the presence or absence of the polymorphism with the respective presence or absence of the autosomal dominant gene associated with high bone mass.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.