DNA encoding lipase from human gastric mucosal tissue
US5691181A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Nov 15, 1994 |
| Grant date | Nov 25, 1997 |
| Priority date | — |
| Expiry date | Nov 15, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A human gastric lipase protein for use in the treatment of lipase deficiency. A process is described for producing gastric lipase using recombinant DNA technology to produce a host organism (for example E. coli) capable of producing a methionine-gastric lipase or precursor of the gastric lipase which may be cleaved to yield the gastric lipase. The host organism is transformed with a vector including a gene coding for a methionine-gastric lipase or a precursor of gastric lipase. The precursor protein is for example, pregastric lipase protein, or a fusion protein comprising gastric lipase and a heterologous protein. A pharmaceutical composition in unit dosage or liquid form is described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.