Improved process for preparing polymyxin B/dextran conjugates

US5691304A · kind A · utility

Assignee

• Novartis AG · CH

Inventors

• Prasad Koteswara Kapa · Parsippany, US
• Gleb Kardash · Rockaway, US
• Andrew Kucerovy · Flanders, US
• Philip Lake · Parsippany, US
• Paul G. Mattner · Staten Island, US
• Russell C. Petter · Stow, US
• Mahavir Prashad · East Hanover, US
• Sushil Sharma · East Hanover, US

Key dates

• Filing date: May 25, 1995
• Grant date: Nov 25, 1997
• Expiry date: May 25, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P39/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An improved process for producing a water-soluble polymyxin B/dextran conjugate comprises the step of reacting polymyxin B or pharmaceutically acceptable salt thereof with dextran in an aqueous media at a pH of about 9.3 to 10.