Nonpeptide endothelin antagonists I

US5691373A · kind A · utility

Assignee

• WARNER-LAMBERT COMPANY LLC · US

Inventors

• Kent Alan Berryman · Ann Arbor, US
• Annette Marian Doherty · Ann Arbor, US
• Jeremy John Edmunds · Ypsilanti, US
• William C. Patt · Chelsea, US
• Mark Plummer · Westbrook, US
• Joseph Thomas Repine · Ann Arbor, US

Key dates

• Filing date: Feb 6, 1995
• Grant date: Nov 25, 1997
• Expiry date: Feb 6, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel nonpeptide antagonists of endothelin I are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, myocardial ischemia, cerebral vasospasm, cerebral ischemia, cerebral infarction, cirrhosis, septic shock, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, hemorrhagic shock, ischemic bowel disease, stroke, benign prosthatic hyperplasia (BPH), and diabetes.