Hydroxamic and carbocyclic acids as metalloprotease inhibitors
US5691381A · kind A · utility
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4Claims
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Key dates
| Filing date | Apr 16, 1996 |
| Grant date | Nov 25, 1997 |
| Priority date | — |
| Expiry date | Apr 16, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides novel hydroxamic acids and carbocyclic acids and derivatives thereof and to pharmaceutical compositions and methods of use of these novel compounds for the inhibition of matrix metalloproteinases, such as stromelysin, and inhibit the production of tumor necrosis factor alpha, and for the treatment of arthritis and other related inflammatory diseases. These novel compounds are represented by Formula I below: ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.