Peptide vaccines and methods relating thereto
US5693325A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Mar 15, 1994 |
| Grant date | Dec 2, 1997 |
| Priority date | — |
| Expiry date | Mar 15, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/16022
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There are disclosed peptide vaccines and methods related thereto for generating a protective immune response in warm-blooded animals. The peptide vaccines comprise a conformationally constrained reverse-turn mimetic, a T cell stimulatory peptide, and a cleavable linker covalently joining the conformationally constrained reverse-turn mimetic and the T cell stimulatory peptide. The conformationally constrained reverse-turn mimetic mimics the three-dimensional structure of an antigenic determinant of a native pathogenic protein and is capable of binding to a B cell. Upon binding to a B cell, the peptide vaccine is internalized, and the T cell stimulatory peptide is released from the conformationally constrained reverse-turn mimetic by cleavage of the cleavable linker. The T cell stimulatory peptide is then expressed on the surface of the B cell in association with class I or II MHC molecules, thus inducing T cell activity and generating a protective immune response.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.