Metal complexed serine protease inhibitors
US5693515A · kind A · utility
18Cited by
9References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 28, 1995 |
| Grant date | Dec 2, 1997 |
| Priority date | — |
| Expiry date | Apr 28, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/811
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Serine protease inhibitors are provided comprising compounds having a P site binding moiety and a divalent cation(s) chelating moiety which are pre-prepared as divalent cation(s) complexes or combined with the serine protease in the presence of divalent cation(s). The compounds are shown to have high inhibitory activity when complexed to divalent cation(s) and find use in various processes associated with serine protease isolation and inhibition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.