Membrane-permeant second messengers

US5693521A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• Roger Y. Tsien · Village of La Jolla, US
• Carsten Schultz · Heidelberg, DE

Key dates

• Filing date: Apr 9, 1993
• Grant date: Dec 2, 1997
• Expiry date: Apr 9, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Acyloxyalkyl esters of phosphate-containing second messengers which are capable of permeating cell membranes. Once inside the cell, the ester derivatives undergo enzymatic conversion to the biologically active form of the second messenger. Acyloxyalkyl esters of second messengers, such as cAMP, cGMP, inositol triphosphate and inositol tetraphosphate are disclosed.