Cyclopeptides of the formula I

US5693612A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Alfred Jonczyk · Darmstadt, DE
• Gunter Holzemann · Seeheim-Jugenheim, DE
• Simon Goodman
• Horst Kessler · Schwalbach, DE
• Roland Haubner · Garching bei München, DE
• Jochen Wermuth · Garching bei München, DE

Key dates

• Filing date: Apr 28, 1995
• Grant date: Dec 2, 1997
• Expiry date: Apr 28, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/27
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to novel cyclopeptides of the formula I EQU cyclo-(Arg-A-Asp-R.sup.1 -R.sup.2) I in which PA0 A, R.sup.1 and R.sup.2 have the meaning given in claim 1, and their salts. These compounds act as integrin inhibitors and can be used in particular for the prophylaxis and treatment of disorders of the circulation, bones and in tumour therapy, and as antimicrobial and antiviral active compounds.