Phenylethyl and phenylpropylamines

US5693630A · kind A · utility

Assignee

• ASTRA CO., LTD. · SE

Inventors

• Stefan Bengtsson · Gately Drive, SE
• Sven Hellberg · Gately Drive, SE
• Nina Mohell
• Lian Chang Zhang · Fujian, CN
• Gerd Hallnemo · Gately Drive, SE
• David Gilbert Jackson · Gately Drive, SE
• Bengt Ulff · Gately Drive, SE

Key dates

• Filing date: Oct 26, 1994
• Grant date: Dec 2, 1997
• Expiry date: Oct 26, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/74
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the general formula ##STR1## or pharmaceutically acceptable salts thereof, wherein Z is a saturated or unsaturated 3 to 6 carbon chain, PA1 m is 2 or 3, PA1 R.sub.1 is a hydrogen atom, or a straight or branched C.sub.1-4 alkyl group, PA1 R.sub.2, R.sub.3 and R.sub.13 are situated in the ortho, meta, or para position of the phenyl ring and are the same or different and selected from the following groups: H, OH, OR.sub.14, halogen, CO.sub.2 R.sub.9, CN, CF.sub.3, NO.sub.2, NH.sub.2, COCH.sub.3,OSO.sub.2 CF.sub.3,OSO.sub.2 CH.sub.3,CONR.sub.10 R.sub.11, OCOR.sub.12, wherein PA1 R.sub.9, R.sub.12 and R.sub.14 is a straight or branched C.sub.1-4 alkyl group, PA1 R.sub.10 and R.sub.11 are the same or different and represents hydrogen or a straight or branched C.sub.1-6 alkyl group, PA1 R is 1) ##STR2## processes for their preparation, pharmaceutical preparations containing them and the use of the compounds in the treatment psychiatric disorders.