Bicyclic fibrinogen antagonists

US5693636A · kind A · utility

Assignee

• SmithKline Beecham Limited · US

Inventors

• William E. Bondinell · Wayne, US
• James Francis Callahan · Philadelphia, US
• William F. Huffman · Malvern, US
• Richard M. Keenan · Malvern, US
• Thomas Wen-Fu Ku · Dresher, US
• Kenneth A. Newlander · West Chester, US

Key dates

• Filing date: Jun 26, 1992
• Grant date: Dec 2, 1997
• Expiry date: Jun 26, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D281/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to compounds of the formula: ##STR1## wherein A.sup.1 to A.sup.5 form an accessible substituted seven-membered ring, which may be saturated or unsaturated, optionally containing up to two heteroatoms chosen from the group of O, S and N wherein S and N may be optionally oxidized; PA1 D.sup.1 to D.sup.4 form an accessible substituted six membered ring, optionally containing up to two nitrogen atoms; PA1 R is at least one substituent chosen from the group of R.sup.7, or Q--C.sub.1-4 alkyl, Q--C.sub.2-4 alkenyl, Q--C.sub.2-4 alkynyl, preferably substituted by an acidic function; PA1 R* is H, Q--C.sub.1-6 alkyl, Q--C.sub.1-6 oxoalkyl, Q--C.sub.2-6 alkenyl or Q--C.sub.2-4 alkynyl, C.sub.3-6 cycloalkyl, Ar or Het, optionally substituted by one or more substitutents; and PA1 R.sup.6 is preferably a substituent containing a basic nitrogen moiety; or a pharmaceutically acceptable salt thereof, which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.