Piperazine derivatives as 5-HT.sub.1A ligands
US5693642A · kind A · utility
7Cited by
1References
6Claims
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Key dates
| Filing date | May 24, 1995 |
| Grant date | Dec 2, 1997 |
| Priority date | — |
| Expiry date | May 24, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D213/38
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Piperazine derivatives of formula (I) and their salts are 5-HT.sub.1A binding agents and may be used, for example, as anxiolytics. In the formula, R, R.sup.2 and R.sup.4 are hydrogen or lower alkyl, R.sup.1 is mono- or bicyclic aryl or heteroaryl, R.sup.3 is lower alkyl or cycloalkyl, A is an alkylene chain and X is --CO--. --CR.sup.5 OH-- (where R.sup.5 is hydrogen, lower alkyl or cycloalkyl), --S--, --SO-- or --SO.sub.2 -- or X can also be --(CH.sub.2).sub.n -- (where n is 0, 1 or 2) when R.sup.3 is cycloalkyl. ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.