3-indolylpiperidines

US5693655A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Henning Bottcher · Darmstadt, DE
• Joachim Marz · Groß-Gerau, DE
• Christoph Seyfried · Seeheim-Jugenheim, DE
• Hartmut Greiner · Darmstadt, DE
• Gerd Bartoszyk · Weiterstadt, DE

Key dates

• Filing date: Apr 21, 1995
• Grant date: Dec 2, 1997
• Expiry date: Apr 21, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

3-Indolylpiperidines of the formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are in each case independently of one another H, A, OH, OA, F, Cl, Br, Z, CN, CF.sub.3, COOH, CONH.sub.2, CONHA, CONA.sub.2, or COOA, or PA1 R.sup.1 and R.sup.2 and also R.sup.3 and R.sup.4 in each case together are also methylenedioxy, PA1 R.sup.5 is H or OH, PA1 R.sup.6 is H or PA1 R.sup.5 and R.sup.6 together are also a bond, PA1 A is alkyl having 1 to 6 C atoms and PA1 n is 2, 3, 4, 5 or 6, and to their physiologically acceptable salts, exhibit action on the central nervous system, in particular dopamine-agonistic or dopamine-antagonistic action.