Process for making HIV protease inhibitors

US5693803A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• David Askin · Hackettstown, US
• Kai Rossen · Hanau, DE
• Paul J. Reider · Westfield, US
• Richard J. Varsolona · Scotch Plains, US
• Ralph P. Volante · Rahway, US
• Kenneth M. Wells · Somerville, US

Key dates

• Filing date: Jun 7, 1995
• Grant date: Dec 2, 1997
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Intermediates of structural formula ##STR1## can be made by reacting a primary or secondary amine with glycosidol or an activated derivative thereof. The process and intermediates are useful for synthesizing HIV protease inhibitor compounds.