(2,3-dihydro-5-benzofuranyl)-acetonitrile

US5693831A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Nikolaus Muller · Monheim, DE
• Guido Steffan · Odenthal, DE

Key dates

• Filing date: Feb 27, 1997
• Grant date: Dec 2, 1997
• Expiry date: Feb 27, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D307/79
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The novel compound (2,3-dihydro-5-benzofuranyl)-acetonitrile is prepared by chloromethylating 2,3-dihydro-benzofuran and reacting the resulting 2,3-dihydro-5-chloromethyl-benzofuran with a cyanide. (2,3-Dihydro-5-benzofuranyl)-acetonitrile can be converted by saponification to (2,3-dihydro-5-benzofuranyl)-acetic acid, an important intermediate for the manufacture of various pharmaceutical active substances. This intermediate has hitherto been obtainable only by a laborious procedure and in low yields.