DNA that encodes a tumor necrosis factor inhibitory protein and a recombinant method of production

US5695953A · kind A · utility

Assignee

• YEDA RESEARCH AND DEVELOPMENT CO. LTD. · IL

Inventors

• David Wallach · Rehovot, IL
• Hartmut Engelmann · Munich, DE
• Dan Aderka · Holon, IL
• Menachem Rubinstein · Nes Ziona, IL

Key dates

• Filing date: Apr 30, 1992
• Grant date: Dec 9, 1997
• Expiry date: Apr 30, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Tumor Necrosis Factor (TNF) Inhibitory Protein is isolated and substantially purified and the DNA that encodes the TNF inhibitory protein, vectors, host cells, and a recombinant method for producing the encoded protein are also set forth. It has the ability to inhibit: (a) the binding of TNF to its receptors, and (b) the cytotoxic effect of TNF. TNF Inhibitory Protein and salts, functional derivatives and active fractions thereof can be used to antagonize the deleterious effects of TNF.