Endothelial PAS domain protein

US5695963A · kind A · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Steven L. McKnight · Dallas, US
• David W. Russell · Dallas, US
• Hui Tian · Cupertino, US

Key dates

• Filing date: Jan 17, 1997
• Grant date: Dec 9, 1997
• Expiry date: Jan 17, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides methods and compositions relating to endothelial PAS domain protein 1 (EPAS1) and related nucleic acids. The proteins may be produced recombinantly from transformed host cells from the disclosed EPAS1 encoding nucleic acids or purified from human cells. The invention provides isolated EPAS1 hybridization probes and primers capable of specifically hybridizing with the disclosed EPAS1 gene, EPAS1-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.