Patent · US Expired

Process for identifying RXR-receptor-agonist compounds

US5696104A · kind A · utility

2Cited by

3References

14Claims

0Family size

Assignee

Centre International de Recherches Dermatalogiques Galderma (C.I.R.D.) Galderma · FR

Inventors

Michel Demarchez · Grasse, FR
Andre Jomard · Grasse, FR

Key dates

Filing date	Jun 19, 1996
Grant date	Dec 9, 1997
Priority date	—
Expiry date	Jun 19, 2016

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K49/0006
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to a process for identifying RXR-agonist molecules, characterized in that it comprises the following steps: (i) a sufficient amount of a compound which is an active ligand for at least one receptor of the super-family of steroidal/thyroidal receptors, other than an RXR-receptor-specific ligand, and which can heterodimerize with the RXRs, is applied topically to a part of the skin of a mammal, (ii) a molecule capable of having an RXR-agonist activity is administered systemically or topically to this same mammal, or to this same part of the skin of the mammal, before, during or after step (i), and (iii) the response on that part of the skin of the mammal thus treated is evaluated.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.