Pyridonecarboxylic acid derivatives
US5696132A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 26, 1994 |
| Grant date | Dec 9, 1997 |
| Priority date | — |
| Expiry date | Jan 26, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Quinolone derivatives are known as synthetic antimicrobial agents having a condensed pyridonecarboxylic acid skeleton, and those having substituents on various replaceable positions of said skeleton are known. In particular, if diastereomers exist, there are 4 or more kinds of stereoisomers. A mixture of diastereomers is a mixture of isomers having different physical properties and is difficult to apply as a drug as such. The present invention provides an antimicrobial 1-(1,2-cis-2-fluorocyclopropyl)-substituted quinolone derivative represented by formula I shown below which, although involving diastereomers, consists of a single stereoisomer. ##STR1## wherein R.sup.1 represents a methyl group, a difluoromethyl group, etc.; R.sup.2 represents a saturated nitrogen-containing heterocyclic group; A represents C--X.sup.3 or a nitrogen atom; X.sup.1 and X.sup.2 each represents a halogen atom; and X.sup.3 and Z represent a hydrogen atom, etc.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.