4-mercaptobenzoylguanidine derivatives

US5696167A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Rolf Gericke · Seeheim-Jugenheim, DE
• Manfred Baumgarth
• Klaus-Otto Minck · Ober-Ramstadt, DE
• Norbert Beier · Reinheim, DE

Key dates

• Filing date: Jan 30, 1996
• Grant date: Dec 9, 1997
• Expiry date: Jan 30, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C323/65
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

4-Mercaptobenzoylguanidines of the formula I ##STR1## in which A, R.sub.1, R.sub.2 and R.sub.3 have the meanings given, and the physiologically unobjectionable salts thereof exhibit antiarrhythmic properties and are active as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.