Antiviral acyclic phosphonomethoxyalkylsubstituted alkenyl and alkynyl purine and pyrimidine derivatives

US5696263A · kind A · utility

Assignees

• Institute of Organic Chemistry and Biochemistry of the Academy of · CZ
• REGA STICHTING, V.Z.W. · BE

Inventors

• Kuo-Long Yu · Hamden, US
• Joanne J. Bronson · Madison, US
• John C. Martin · Los Alamos, US

Key dates

• Filing date: Dec 6, 1994
• Grant date: Dec 9, 1997
• Expiry date: Dec 6, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6512
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds are provided that generally have the structure BCH.sub.2 CH(R)OCH.sub.2 P(O)(OH).sub.2, wherein B is a purinyl or pyrimidinyl base and R is C.sub.1-2 alkyl substituted with azido or amino, straight or branched alkenyl of 2-6 carbon atoms or alkynyl of 2-6 carbon atoms, together with the monester and diesters of such compounds with a C.sub.1-5 alkanol, and the corresponding salts, hydrates, solvates, the (R) or (S) isomers and the racemic (RS) mixtures thereof. The compounds have desirable antiviral activity.