Process for the stereoselective reduction of steroid enelactams
US5696266A · kind A · utility
10Cited by
28References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 28, 1995 |
| Grant date | Dec 9, 1997 |
| Priority date | — |
| Expiry date | Jul 28, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J9/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The novel process of this invention involves the reduction of certain .DELTA.-5 steroidal alkenes to selectively produce either the 5.alpha. or 5.beta. reduction products. Particularly, this invention involves reduction of .DELTA.-5 steroidal alkenes using a rhodium based catalyst in the presence of hydrogen to selectively yield 5.alpha. steroids or alternatively reduction of .DELTA.-5 steroidal alkenes in an ionizing medium with a trialkylsilane to selectively yield 5.beta. steroids.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.