Biologically active vasopressin analogues

US5698516A · kind A · utility

Assignee

• Ferring B.V. · NL

Inventors

• Anders Nilsson · Västerås, SE
• Håkan Olson · Lund, SE
• Christina Soderberg-Ahlm · Malmö, SE
• Jerzy Trojnar · Vintrie, SE

Key dates

• Filing date: Dec 18, 1995
• Grant date: Dec 16, 1997
• Expiry date: Dec 18, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/15
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Vasopressin analogues of formula (I) ##STR1## wherein X is (S)-2-amino-2-methyl-butanoic acid (CaMeAbu) or Valine (Val), Y is Thienylalanine (Thi) or Methionine (Met), Z is D-Phenylalanine (D-Phe) or D-Thienylalanine (Thi) or D-Tyrosine (D-Tyr), are disclosed. Pharmaceutical preparations comprising a vasopressin analogue of the invention as active ingredient are disclosed and exemplified by oral preparations, nasal preparations, and intravenous preparations. The vasopressin analogues of the invention are intended for use as a medicament, specially an antidiuretic agent. The antidiuretic agent is preferably used for the treatment of diabetes insipidus or enuresis.