2,4-diphosphonoglutaric acid derivatives, processes for their production and pharmaceutical agents containing these compounds

US5698541A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Gerd Zimmermann · Eckental, DE
• Angelika Esswein · Büttelborn, DE
• Christos Tsaklakidis · Weinheim, DE
• Frieder Bauss · Lambsheim, DE

Key dates

• Filing date: Sep 25, 1996
• Grant date: Dec 16, 1997
• Expiry date: Sep 25, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/572
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention concerns compounds of the general formula I ##STR1## in which R denotes a lower alkyl which can be substituted if desired by hydroxy, alkoxy, amino, dialkylamino, alkylmercapto, alkylsulfinyl, alkanesulfonyl, cycloalkyl, aryl or a heterocyclic ring, or it denotes lower alkenyl, cycloalkyl, cycloalkenyl, aryl or a heterocyclic ring and PA1 R.sub.1 and R.sub.2 can be, independently of one another, hydrogen, lower alkyl, cycloalkyl, aryl or arylmethyl, their optically active salts as well as their pharmacologically acceptable salts, processes for their production as well as pharmaceutical agents which contain these compounds for treating diseases of calcium metabolism. Moreover the invention concerns compounds of formula II as intermediate products for the production of compounds of formula I.