Cyclic polyamines

US5698546A · kind A · utility

Assignee

• Johnson Matthey Public Limited Company · GB

Inventors

• Gary Bridger · Bellingham, US
• Sreenivasan Padmanabhan · Exton, US
• Renato Skerlj · Vancouver, CA

Key dates

• Filing date: Jun 20, 1996
• Grant date: Dec 16, 1997
• Expiry date: Jun 20, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Linked polyamine cyclic compounds of general formula V--R--A--R'--W where V and W are independently cyclic polyamine moieties having from 9 to 32 ring members and 3 to 8 amine nitrogens and having either one or more aromatic rings fused thereto or a heteroatom other than nitrogen incorporated in the ring, A is an aliphatic or aromatic moiety and R and R' are each a linking chain, possess improved partition coefficients at biologically relevant pH compared to known compounds, and possess high anti-HIV activity.