Hydroxy-substituted antifungals

US5698557A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Anil K. Saksena · Upper Montclair, US
• Viyyoor M. Girijavallabhan · Parsippany, US
• Raymond G. Lovey · West Caldwell, US
• Russell E. Pike · Stanhope, US

Key dates

• Filing date: Jun 17, 1996
• Grant date: Dec 16, 1997
• Expiry date: Jun 17, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6518
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound represented by the formula I ##STR1## wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R.sub.1 is a straight or branched chain (C.sub.3 to C.sub.8) alkyl group substituted by one or two hydroxy moieties, an ether or ester thereof (e.g., a polyether ester, heterocyclic ester amino acid ester or phosphate ester) thereof and the carbon with the asterisk (*) has the R or S absolute configuration or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.