Substituted benzenesulfonylureas and thioureas process for their preparation and their use as pharmaceuticals

US5698596A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Heinrich Englert · Hofheim, DE
• Dieter Mania · Königstein, DE
• Jens Hartung · Rodgau, DE
• Heinz Gogelein · Frankfurt am Main, DE
• Joachim Kaiser · Frankfurt am Main, DE
• Wolfgang Linz · Mainz, DE
• David G. Wettlaufer · Phillipsburg, US

Key dates

• Filing date: Sep 3, 1996
• Grant date: Dec 16, 1997
• Expiry date: Sep 3, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C335/42
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Substituted benzenesulfonylureas and -thioureas--processes for their preparation and their use as pharmaceuticals Benzenesulfonylureas and -thioureas of the formula I ##STR1## where R(1) is H or (fluoro)methyl, R(2) is H, Hal or (fluoro)(mercapto)alk(oxy)yl, E is O or S; Y is --CR(3).sub.2 !.sub.n --, where R(3)=H or alkyl and n=1-4, X is H, Hal or alkyl and Z is Hal, NO.sub.2 or alk(yl)oxy, are described. The compounds I are used for treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrhythmia, and can therefore be used as antiarrhythmics. They are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.