Morpholino-subunit combinatorial library and method
US5698685A · kind A · utility
373Cited by
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10Claims
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Key dates
| Filing date | Mar 31, 1995 |
| Grant date | Dec 16, 1997 |
| Priority date | — |
| Expiry date | Mar 31, 2015 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2219/0072
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of generating a compound capable of interacting specifically with a selected macromolecular ligand is disclosed. The method involves contacting the ligand with a combinatorial library of oligomers composed of morpholino subunits with a variety of nucleobase and non-nucleobase side chains. Oligomer molecules that bind specifically to the receptor are isolated and their sequence of base moieties is determined. Also disclosed is a combinatorial library of oligomers useful in the method and novel morpholino-subunit polymer compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.