Modified ribozymls

US5698687A · kind A · utility

Assignee

• Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US

Inventors

• Fritz Eckstein · Göttingen, DE
• Wolfgang Pieken · Boulder, US
• Fritz Benseler · Oettingen, DE
• David B. Olsen · Johnstown, US
• David M. Williams · Cambridge, GB
• Olaf Heindenreich · Göttingen, DE

Key dates

• Filing date: May 4, 1995
• Grant date: Dec 16, 1997
• Expiry date: May 4, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/322
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention refers to an RNA molecule with catalytic activity comprising at least one modified nucleoside, wherein the hydroxy group at the 2'-position of the fibose sugar is replaced by a modifier group, selected from halo, sulfhydryl, azido, amino, monosubstituted amino, and disubstituted andno groups, a process for the preparation of modified KNA molecules and the use of modified KNA molecules as therapeutic agents and biocatalysts.