N-nitroso-N-substituted hydroxylamines as nitric oxide donors
US5698738A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | May 15, 1995 |
| Grant date | Dec 16, 1997 |
| Priority date | — |
| Expiry date | May 15, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/36
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Nitric oxide has proved to mediate many important physiological processes. The nitric oxide donors of the present invention have a NONOate anion linked to an ortho-substituted aryl, a heteroaromatic substituent, asteroid, or a catecholamine. Preferred ortho substituents are alkoxy, halo, and alkyl. The cation of the salt is an alkali metal, an alkaline-earth metal, an ammonium or substituted ammonium group. Nitric oxide donors provided herein are more stable than that of nitrogen-bonded NONOates described previously. The by product left after release of NO, and the nitric oxide donors themselves, are very probably less carcinogenic than the corresponding nitrogen-bonded NONOates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.