Transgenic animals lacking prion proteins
US5698763A · kind A · utility
16Cited by
2References
7Claims
0Family size
Inventors
Key dates
| Filing date | Jun 21, 1994 |
| Grant date | Dec 16, 1997 |
| Priority date | — |
| Expiry date | Jun 21, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to transgenic mammals and birds that are not susceptible to spongiform encephalopathies (i.e., scrapie-like or prion diseases), due to absence of endogenous functional prion protein ("PrP"). More particularly, this invention relates to DNA targeting molecules that specifically disrupt PrP genes by homologous recombination in transfected animal cells, to cultured cells transformed with such DNA targeting molecules, and to animals derived from those transformed cells and the transgenic progeny of such animals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.