Transgenic mice expressing HPV early region oncogene develop progressive epithelial neoplasia

US5698764A · kind A · utility

Assignees

• The Regents of the University of California · US
• The United States of America, as represented by the Secretary, Health and Human Services · US

Inventors

• Jeffrey M. Arbeit · San Francisco, US
• Douglas Hanahan · San Francisco, US
• Peter M. Howley · Wellesley, US

Key dates

• Filing date: Jun 9, 1994
• Grant date: Dec 16, 1997
• Expiry date: Jun 9, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2830/008
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention relates to improved models for progressive epithelial neoplasias and methods for their use. In particular, the invention provides transgenic mice comprising a human papilloma virus early region oncogene operably linked to a promoter which directs expression of the oncogene in a transient amplifying cell in the mice.