Pharmacological composition containing polyelectrolyte complexes in microparticulate form and at least one active agent

US5700459A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Volker Krone · Flörsheim, DE
• Michael Magerstadt · Hofheim, DE
• Axel Walch · Baldham, DE
• Albrecht Groner · Seeheim-Jugenheim, DE
• Dieter Hoffmann · Marburg, DE

Key dates

• Filing date: Nov 16, 1994
• Grant date: Dec 23, 1997
• Expiry date: Nov 16, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a pharmacological composition comprising a polyelectrolyte complex, in particular a polyacid with an average particle size of less than 15 .mu.m and an active agent, among which are active peptides, proteins, enzymes, enzyme inhibitors, antigens, cytostatics, antiinflamatory agents, antibiotics and vaccines. The said composition ensures that the active agent is converted in a non-deleterious manner into a form which can be administered. In addition, the biodistribution, bioavailability and absorption of the pharmaceutical are beneficially affected.