Sustained release microparticulate caffeine formulation
US5700484A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 16, 1996 |
| Grant date | Dec 23, 1997 |
| Priority date | — |
| Expiry date | Aug 16, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/5078
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to compositions and methods for increasing the alertness of an individual through the administration of a stimulant such as xanthine or an xanthine derivative and preferably caffeine. A particular composition has one or more layers containing the stimulant arranged about the cores of microparticles. This allows the composition to release a significant portion of the stimulant within about two hours after administration so that a level of alertness can be readily achieved. Thereafter, the balance of the composition is released within about 6 to 10 hours, so that the stimulant can provide alertness during that time, but then can dissipate to levels which would not affect the individual's ability to sleep. Also, the formulation is carefully designed so that the stimulant does not accumulate in the individual's system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.