Piperazine derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them

US5700801A · kind A · utility

Assignee

• Karl Thomae GmbH · DE

Inventors

• Helmut Pieper · Lohr am Main, DE
• Volkhard Austel · Biberach, DE
• Frank Himmelsbach · Mittelbiberach, DE
• Gunter Linz · Mittelbiberach, DE
• Brian Guth · Warthausen, DE
• Johannes Weisenberger · Biberach, DE

Key dates

• Filing date: Dec 13, 1995
• Grant date: Dec 23, 1997
• Expiry date: Dec 13, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Piperazine derivatives useful in the treatment or prevention of inflammation, bone degradation, thrombosis and tumor metastasis. Exemplary species are: PA0 (a) 4-trans-3-4-(4-Pyridyl)-piperazin-1-yl!propionyl!amino!-cyclohexanecarb oxylic acid, PA0 (b) 3-4-trans-4-(4-Pyridyl)-piperazin-1-yl!carbonylamino!-cyclohexylpropioni c acid, PA0 (c) 3-4-trans-4-(4-Pyridyl)-piperazin-1-yl!malonylamino!cyclohexylcarboxylic acid, PA0 (d) Methyl 4-trans-3-4-(4-pyridyl)-piperazin-1-yl!-propionyl!-amino!cyclohexane carboxylate, PA0 (e) Methyl 3-4-trans-4-(4-pyridyl)-piperazin-1-yl!-carbonylamino!cyclohexyl propionate, PA0 (f) Methyl 4-trans-4-(4-pyridyl)-piperazin-1-yl!-malonylamino!-cyclohexyl carboxylate, PA0 (g) Cyclohexyl 4-trans-4-(4-pyridyl)-piperazin-1-yl!-acetyl!-amino!-cyclohexane carboxylate, and PA0 (h) Isobutyl 4-trans-4-(4-pyridyl)-piperazin-1-yl!-acetyl!-amino!-cyclohexane carboxylate.