2-substituted benzothiazole derivatives and prophylactic and therapeutic agents for the treatment of diabetic complications
US5700819A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 22, 1995 |
| Grant date | Dec 23, 1997 |
| Priority date | — |
| Expiry date | Nov 22, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D277/64
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Unique benzothiazole derivatives which exert superior aldose redactase inhibiting actions are unexpectedly and advantageously useful in the prophylactic and therapeutic treatment of diabetic complications. A benzothiazole derivative compound of the formula (1): ##STR1## wherein X is halogen, R.sup.1 and R.sup.2, which are the same or different, are each independently hydrogen or halogen, A is a methylene group or a sulfur atom, and --B--COOR.sup.3 is a group as defined in the specification; or a pharmaceutically acceptable salt and a pharmaceutical composition comprising the same which is a useful prophylactic or therapeutic agent for the treatment of diabetic complications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.