Use of reporter genes for retinoid receptor screening assays having novel retinoid-associated response elements
US5702914A · kind A · utility
68Cited by
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24Claims
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Key dates
| Filing date | Dec 21, 1994 |
| Grant date | Dec 30, 1997 |
| Priority date | — |
| Expiry date | Dec 21, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
In accordance with the present invention, there are provided novel cotranscription factors that function to enhance mRNA transcription in cooperation with retinoid receptors. Also provided are novel DNA response elements, DNA constructs and expression vectors containing said constructs useful for providing cell-specific gene expression. Bioassays are also provided that are useful for evaluating whether a compound is a functional ligand (e.g., agonist or antagonist) for retinoid receptor protein(s), or functional engineered or modified forms thereof.
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