Microbiological process for the preparation of heteroaromatic carboxylic acids using Alcaligenes faecalis
US5702930A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 6, 1996 |
| Grant date | Dec 30, 1997 |
| Priority date | — |
| Expiry date | Jun 6, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P17/12
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A microbiological process for the preparation of a heteroaromatic carboxylic acid or one of its physiologically tolerated salts of the formulae I or II: ##STR1## wherein R.sub.1 and R.sub.2 are identical or different and each denotes a hydrogen or halogen atom, and X denotes a nitrogen atom or CH--, from a heteroaromatic nitrile of the formulae III or IV, respectively: ##STR2## First, a microorganism, Alcaligenes faecalis (DSM 6335), is cultured in the presence of an inducer, 2-cyanopyridine, and a carbon source such as a dicarboxylic acid, a tricarboxylic acid or a carbohydrate. Substrate III or IV is then reacted with the cultured microorganism. The biotransformation is carried out under anaerobic conditions for compounds of the formula I, and under aerobic conditions for compounds of the formula II.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.