Patent · US Expired

Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs

US5703073A · kind A · utility

60Cited by

8References

20Claims

0Family size

Assignee

Nitromed, Inc. · US

Inventors

David S. Garvey · Dover, US
L. Gordon Letts · Dover, US
H. Burt Renfroe · Wellesley, US
Sang William Tam · Dover, US

Key dates

Filing date	Oct 13, 1995
Grant date	Dec 30, 1997
Priority date	—
Expiry date	Oct 13, 2015

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitrogen monoxide group (preferably as a charged species, particularly nitrosonium); and methods of treatment of inflammation, pain, gastrointestinal lesions and/or fever using the compositions are disclosed. The compounds and compositions protect against the gastrointestinal, renal and other toxicities that are otherwise induced by nonsteroidal antiinflammatory drugs.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.