Method for stabilizing duocarmycin derivatives
US5703080A · kind A · utility
114Cited by
2References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 30, 1996 |
| Grant date | Dec 30, 1997 |
| Priority date | — |
| Expiry date | Oct 30, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Stabilized duocarmycin derivatives represented by formula (I): ##STR1## wherein R is lower alkyl, allyl or benzyl, and X is Cl or Br, are prepared by adding at least a compound selected from the group consisting of a saccharide, an electrolyte, a water-soluble polymer, a polyhydric alcohol and a surfactant to a solution containing the duocarmycin derivatives. Also provided are freeze-dried pharmaceutical preparations containing the stabilized duocarmycin derivatives.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.