Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5703093A · kind A · utility
46Cited by
41References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 31, 1995 |
| Grant date | Dec 30, 1997 |
| Priority date | — |
| Expiry date | May 31, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Tetrahydrofurans, tetrahydrothiophenes, pyrrolidines and cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammatory or immune response. It has been determined that 5-lipoxygenase activity, oral availability, and stability in vivo (for example, glucuronidation rate) can vary significantly among the optical isomers of the disclosed compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.