Phenoxyacetic acid derivatives
US5703099A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 3, 1996 |
| Grant date | Dec 30, 1997 |
| Priority date | — |
| Expiry date | May 3, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
We proposed a novel compound having an activity of PGI.sub.2 receptor agonist. A phenoxyacetic acid derivative of the formula ##STR1## A is --C(R.sup.1).dbd.N.about.OR.sup.2, --CH(R)NH--OR.sup.2, --COE, --SO.sub.2 E, --CH.sub.2 --NR.sup.3 --Y, --Z--NR.sup.3 --CONR.sup.4 R.sup.5, --CH.sub.2 --OR.sup.6, --CO.sub.2 R.sup.6, --CH.sub.2 --O.about.N.dbd.CR.sup.7 R.sup.8, --CH.sub.2 --O--NHCHR.sup.7 R.sup.8, substituted by imidazolyl(methyl), pyrazolylmethyl, oxazolyl(methyl), thioxazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolylmethyl; PA1 T is alkylene, alkenylene, etc.; PA1 D is --CO.sub.2 R.sup.10, --CONR.sup.11 R.sup.12 ; PA1 E is (substitution) amino, hydradino; PA1 Y is substituted (thio) carbonyl, substituted sulfonyl; PA1 Z is --CH.dbd.N--, --CH.sub.2 NR.sup.3 --; PA1 R.sup.1, R.sup.3, R.sup.10 -R.sup.13 is each H or alkyl, etc.; PA1 R.sup.2, R.sup.4 -R.sup.9 is each H, alkyl or alkyl substituted by phenyl or hetero ring, etc. and non-toxic salts thereof, non-toxic acid addition salts thereof, possess an agonistic on PGI.sub.2 receptor, so it is useful for prevention and/or treatment of thrombosis, arteriosclerosis, ischemic heart diseases, gastric ulcer and hypertension.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.