Hydrolysis-promoting hydrophobic taxane derivatives
US5703117A · kind A · utility
5Cited by
1References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 12, 1996 |
| Grant date | Dec 30, 1997 |
| Priority date | — |
| Expiry date | Sep 12, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D305/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein is a taxane having a hydrocarbon attached at the 2' and/or 7 positions, the hydrocarbon's alpha position being occupied by a "hydrolysis-promoting group" ("HPG"). Substitution of an HPG for the methylene unit ordinarily occupying the alpha position allows for enhanced in vivo hydrolysis of the hydrocarbon-taxane bond, and hence, for enhanced taxane therapeutic activity. Also provided herein are taxane-containing compositions, and methods of administering taxanes to animals, including those afflicted with cancers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.