Ascorbic acid compositions for reducing irritation of topically applied active ingredients
US5703122A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Feb 6, 1996 |
| Grant date | Dec 30, 1997 |
| Priority date | — |
| Expiry date | Feb 6, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61Q19/007
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The use of an effective amount of ascorbic acid (Vitamin C) or one or more of its derivatives, has been found to decrease skin irritation caused by the topical administration of an active ingredient for treating a skin condition. Examples of the active ingredient include .alpha.-hydroxy acids, .beta.-hydroxy acids, keto acids, benzoyl peroxide, retinol (Vitamin A), retinoic acid, retinal A.sub.2, Vitamin A epoxide, lactamides and quaternary ammonium lactates, C.sub.4-12 hydroxylated carboxylic acids, sulfur, resorcinol and salicylic acid, and various derivatives thereof. The ascorbic acid (or its derivatives) is present in effective amounts from about 0.5% to about 25% by weight. It is provided by topical application of a separate solution or by admixture with a cosmetically or pharmaceutically acceptable vehicle for the active ingredient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.