Protein active in humoral hypercalcemia of malignancy-PTHrP

US5703207A · kind A · utility

Assignee

• The University of Melbourne · AU

Inventors

• Thomas Martin · Konstanz, DE
• Jane M. Moseley · Melbourne, AU
• Bruce E. Kemp · Melbourne, AU
• Richard E. H. Wettenhall · Melbourne, AU

Key dates

• Filing date: Dec 9, 1994
• Grant date: Dec 30, 1997
• Expiry date: Dec 9, 2014

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/975
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A sub-unit or fragment of parathyroid hormone related protein having the following characteristics: PA1 (a) an N-terminal amino acid sequence A V S E H Q L L H D K G K S I Q D L R R R F F L H H L I A E I H T A E I R A T S E V S P N; PA1 (b) a molecular weight between 15 to 25 kilodaltons, as determined by sodium dodecyl polyacrylamide gel electrophoresis under reducing and non-reducing conditions; and PA1 (c) a specific biological activity of at least about 6 mg equivalents of a peptide composed of amino acids 1-34 a parathyroid hormone related protein per mg protein as measured in an adenylate cyclase response assay.