Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
US5705178A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 8, 1993 |
| Grant date | Jan 6, 1998 |
| Priority date | — |
| Expiry date | Dec 8, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L31/042
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. Anionic polymers for use in the invention include but are not limited to natural proteoglycans, and the glycosaminoglycan moieties of proteoglycans. Additionally, anionic carbohydrates and other anionic polymers may be used. The anionic polymers dextran sulfate and pentosan polysulfate are preferred. In a more preferred embodiment, dextran sulfate, in which the sulfur content is greater than about 10% by weight, may be used. In a more preferred embodiment, the average molecular weight is about 40,000 to 500,000 Daltons. The present invention further provides compositions and methods to inhibit glial cell invasion, detrimental bone growth and neurite outgrowth. In a preferred embodiment, the inhibitory compositions further comprise an adhesive protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.