Method of producing flowable R,S-thioctic acid, R,S-thioctic acid and its use

US5705192A · kind A · utility

Assignee

• Asta Medica Aktiengesellschaft · DE

Inventors

• Horst Bethge · Hanau, DE
• Kurt Klostermann
• Roland Moller · Herbrechtingen, DE
• Gerhard Sator · Dieburg, DE

Key dates

• Filing date: Mar 20, 1996
• Grant date: Jan 6, 1998
• Expiry date: Mar 20, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/385
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

1. A method of producing flowable R,S-thioctic acid, R,S-thioctic acid and its use. 2.1. Known methods of preparing flowable thioctic acid which can be galenically further processed by pressing to highly-concentrated, solid presentations with active-substance contents of more than 200 mg pure substance require the mixing of the thioctic-acid forms of different origins and/or a spraying on of galenic adjuvants from aqueous solution and a subsequent grinding process in order to arrive at a pressable granulate. 2.2. As a result of the fact that thioctic acid of any origin is placed in the fluid bed of a device suited for producing a fluid bed and that a built-up granulate consisting of thioctic acid is obtained by spraying a solution of thioctic acid of any origin onto the matter placed in the fluid bed under simultaneous removal of the solvent, it is possible to make a thioctic-acid form available which does not adhere to the pressing tool or exhibit a tendency to form fissures on the tablet even when tablets with 600 mg or more active-substance content are prepared. The novel R,S-thioctic acid has a specific surface of >0.7 m.sup.2 /g and a number of mesopores with a diameter betwee…