High-throughput screening assay for inhibitors of nucleic acid helicases
US5705344A · kind A · utility
9Cited by
4References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 14, 1996 |
| Grant date | Jan 6, 1998 |
| Priority date | — |
| Expiry date | Mar 14, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/68
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides screening assays for identifying an inhibitor of a pathogenic helicase activity, e.g. a helicase derived from a pathogenic infectious organism such as a bacterium, protozoan or fungus. Helicase activity is detected by the solid-phase, preferential capture of retained (non-liberated) single-stranded nucleic acid comprising a detectable label.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.