Cyclopeptides

US5705481A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Alfred Jonczyk · Darmstadt, DE
• Gunter Holzemann · Seeheim-Jugenheim, DE
• Brunhilde Felding-Habermann · Village of La Jolla, US
• Friedrich Rippmann · Heidelberg, DE
• Guido Melzer · Hofheim, DE
• Beate Diefenbach · Darmstadt, DE

Key dates

• Filing date: May 8, 1995
• Grant date: Jan 6, 1998
• Expiry date: May 8, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to novel cyclopeptides of the formula I EQU cyclo-(A-B-C-D-Arg) I in which PA1 A and B are each independently of one another Ala, Asn, Asp, Arg, Cys, Gln, Glu, Gly, His, Ile, Leu, Lys, Met, Phe, Pro, Ser, Thr, Trp, Tyr or Val; PA1 C is Asp or Asp(O--C.sub.1-4 -alkyl); and PA1 D is Gly or Ala; at least two of the amino acid radicals stated being present in the D-form; and their salts. These compounds act as integrin inhibitors and can be used in particular for the prophylaxis and treatment of disorders of the circulation and in tumor therapy.